Choline salicylate


Generic Medicine Info
Indications and Dosage
Buccal
Mouth lesions
Adult: Apply 8.7% gel on affected area.

Oral
Fever, Pain
Adult: 435-870 mg every 4 hr when required.

Oral
Rheumatic disorders
Adult: 4.8-7.2 g daily in divided doses.
Contraindications
Haemophilia, haemorrhagic disorders, gout, history of hypersensitivity to salicylates. Severe renal or hepatic impairment; childn <12 yrs. Pregnancy and lactation.
Special Precautions
Peptic ulcers, errosive gastritis; asthma, allergic disorders; renal and hepatic impairment; dehydrated patients; uncontrolled hypertension; elderly.
Adverse Reactions
GI disorders, fatigue, hypersensitivity reactions, skin eruptions, haemolytic anaemia, weakness, dyspnoea; local irritation (rectally); Reye's syndrome.
Potentially Fatal: Paroxysmal bronchospasm; hepatotoxicity; renal impairment; thrombocytopenia, iron-deficiency anaemia, occult bleeding, leukopenia; mild chronic salicylate intoxication.
Drug Interactions
Increased toxicity of warfarin. Antacids may reduce salicylate effects. Increased risk of GI bleeding when used with corticosteroids.
Lab Interference
Interfere with thyroid function test.
Action
Description:
Mechanism of Action: Choline salicylate alleviates pain by inhibition of prostaglandin synthesis and reduce fever by acting on the hypothalamus heat-regulating center. It also blocks the generation of impulses.
Onset: 1-2 hr.
MIMS Class
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) / Preparations for Oral Ulceration & Inflammation
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